XtalPi and CK Life Sciences Ink Agreement to Develop Cancer Molecular Diagnostic Models using AI and Biomarker Data


SHENZHEN, China, Nov. 6, 2023 /PRNewswire/ — Today, XtalPi, a leading global technology company in combining artificial intelligence (AI) and robotics to drive the discovery of groundbreaking medicine and innovative materials, announced the signing of a new agreement with CK Life Sciences, a member of the CK Hutchison Group. Expanding upon their existing partnership, the two companies will combine AI algorithms with anonymized clinical and biomarker data from cancer patients and healthy individuals in CK Life Sciences’ data repository to jointly explore and develop miRNA-based postoperative molecular diagnostic models for prognostic risk prediction. With the help of AI and machine learning models, this collaborative engagement will hopefully lead to the development of more advanced and intelligent solutions for the processing and modeling of holistic multidimensional biomedical data, biomarker discovery, and postoperative recurrence risk prediction.

Modern experimental techniques have advanced significantly in clinical research, resulting in a wealth of data from various dimensions such as genomics, cell biology, and tissue analysis. This combination, empowered by the rapid development of artificial intelligence technologies, presents unprecedented opportunities for clinical research and drug discovery. Early diagnosis is a prime example where significant medical resources can be conserved through the development of better AI prediction methods. In recent years, with the continuous decrease in the cost of high-throughput sequencing, the industry has witnessed a steady increase in real-world mRNA and miRNA data accumulated in clinical treatment. AI algorithms offer new and exciting possibilities for extracting valuable insights from such large-scale complex data sets that are beyond the scope of human perception. This innovative approach has the potential to identify new disease biomarkers and facilitate the development of efficient models for molecular diagnosis. The application of AI in this context holds immense promise for accurately predicting postoperative prognosis and recurrence risk among cancer patients, while simultaneously reducing the wastage of valuable medical resources. As a result, this rapidly evolving field has garnered significant interest from healthcare professionals and industry experts alike.

XtalPi, an AI and robotics technology company with a proven track record of success in applying and developing cutting-edge algorithms in life science research, offers unique advantages and extensive experience in biological sequence data modeling, particularly in the areas of proteins and genes. CK Life Sciences is actively engaged in the R&D of therapeutic cancer vaccines and cancer diagnostics. With a repository of cancer biomarker and clinical data through years of clinical research, CK Life Sciences aims to leverage its expertise and strategic relationships to revolutionize cancer care, striving for improved patient outcomes through cutting-edge research in the field of cancer diagnostics.

In 2022, the two companies signed a collaboration to jointly develop a novel AI tumor vaccine R&D platform to improve the discovery and design capabilities of tumor vaccines and accelerate the development of more vaccine types. This new agreement will focus on a specific type of cancer, where XtalPi will build AI models based on an extensive collection of de-sensitized multi-dimensional molecular diagnostic data in CK Life Sciences’ repository.

The primary objective of this project is to develop groundbreaking modeling capabilities for miRNA data. By doing so, XtalPi and CK Life Sciences aim to create clinically applicable, high-precision tumor diagnostic tools that can enhance physicians’ ability to reliably assess postoperative cancer recurrence risks among patients and implement better-tailored treatment plans to improve patient survival rates and quality of life. Concurrently, the two companies will endeavor to identify crucial biomarkers and develop robust computational models for clinical diagnosis, disease management, and the discovery of novel therapeutics. The models and methods derived from this project will lay the foundation for future collaborations involving larger and more complex datasets.

In the future, the application of these models and tools holds the potential for encompassing a wide range of disease areas, with their usage extending to the analysis of heterogeneous omics data, including genomics, proteomics, and metabolomics. This will enable the integration of multi-modal data, such as genomics and imaging data, bolstering crucial applications such as biomarker identification, clinical diagnosis, novel drug discovery, and drug repositioning.

Dr. Lipeng Lai, co-founder and CIO of XtalPi
Dr. Lipeng Lai, co-founder and CIO of XtalPi

Dr. Lipeng Lai, co-founder and Chief Innovation Officer of XtalPi, said, "CK Life Sciences has a stellar scientific team and has accumulated large-scale, high-quality clinical molecular diagnostic data, which is integral to this collaboration. Combined with XtalPi’s capabilities in AI model construction and industry experience in applying cutting-edge technologies such as large language models, we expect to achieve novel breakthroughs in this collaboration and accelerate the development of better molecular diagnostic solutions. We look forward to exploring together with CK Life Sciences a set of AI solutions that can be used for diverse data and improve biomarker discovery and clinical diagnosis for the ultimate benefit of patients worldwide."

Dr. Melvin Toh, Vice President and Chief Scientific Officer of CK Life Sciences
Dr. Melvin Toh, Vice President and Chief Scientific Officer of CK Life Sciences

Dr. Melvin Toh, Vice President and Chief Scientific Officer of CK Life Science, remarked, "Diagnostic and prognostic tests play a crucial role in cancer management, representing a significant aspect of comprehensive cancer care. The timely detection of cancer enables early intervention, facilitating prompt treatment initiation. Concurrently, the identification of patients at higher risk of recurrence or disease progression aids in tailoring treatment strategies based on risk. Working with XtalPi’s exceptional team of data scientists, we hope to leverage our collective strengths to develop innovative cancer molecular diagnostics that will lead to improved patient outcomes."

About XtalPi

XtalPi is an innovative technology company powered by artificial intelligence (AI) and robotics. Founded in 2014 on the MIT campus, XtalPi is dedicated to driving intelligent and digital transformation in the life science and new materials industries. With tightly interwoven quantum physics, AI, cloud computing, and large-scale clusters of robotic workstations, XtalPi offers a range of technology solutions, services, and products to accelerate and empower innovation for companies in the biopharmaceutical, chemical, new energy, and new materials sectors worldwide.

About CK Life Sciences

CK Life Sciences (stock code: 0775) is listed on the Stock Exchange of Hong Kong. Bearing the mission of improving the quality of life, CK Life Sciences is engaged in the business of research and development, manufacturing, commercialisation, marketing, sale of, and investment in, products and assets which fall into three core categories – nutraceuticals, pharmaceuticals & diagnostics, and agriculture-related. CK Life Sciences is a member of the CK Hutchison Group.

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